There are many anecdotal reports of patients getting relief by using a topical antiseptic in the gluteal crease. This may be helpful in minimizing the frequency of infections, but there are no good studies to confirm this. Most important, is that the antiseptic dry completely after application and not irritate the skin. If it irritates the skin, it may cause swelling of the pores and cause infection rather than prevent it. Common homeopathic antiseptics are tea tree oil, garlic, fenugreek, turmeric, coconut oil, Epsom salts, castor oil, grape seed oil, oregano oil, CBD oil, vinegar, baking soda, Manuka honey, OXY pads, and aloe vera. Again, I must stress that this may minimize frequency of infection, but not cure the problem, and I do not recommend any of these treatments. I would avoid antibiotic ointments, because ointments keep the area chronically moist, which is not healthy for the skin.
When topical treatments are recommended it is often not specified that some of these are only for use on intact skin, others are to help an abscess drain, and others are for open wounds. These remedies are often given a blanket recommendation for all pilonidal disease which is not appropriate, and at times not safe. (For example, tea tree oil is to be put on intact skin, while Manuka honey is to help an open wound heal.)