There are no known creams, lotions, homeopathic remedies, antiseptics, or antibiotics that will make pilonidal disease under the skin resolve. It is possible, with diligent wound care to get the outward openings, such as the sinus tracts or pores, to heal shut temporarily; and antibiotics can make the pain and infection of a flare up subside. But, the disease can still exist under the skin waiting for a time to become symptomatic. The most effective way to promote external healing is to allow air to circulate around the affected skin by placing a dry gauze pad between the buttocks and changing it frequently. Some patients have described temporary success with topical Tea Tree Oil, oregano oil, or MediHoney – which are effective antimicrobials and anti-inflammatory agents. But, they do not address the basic cause of the problem, which is a deep cleft; nor do they address the tunnels and pockets of hair under the skin.
It is not unreasonable to try these topical methods – but it often leads to a disappointing recurrence. Long term use of these topical agents just turns a curable problem into a chronic disease.